Severson, David L.; Khalid, Ahmed Murtaz; Aasum, Ellen; Hafstad, Anne D.; Lund, Trine; Larsen, Terje S. (Journal article; Tidsskriftartikkel, 2009-01-16)
The plasma supply of energy substrates plays a key role in determining the cardiac metabolic
phenotype. In diabetes, a high plasma supply of fatty acids (FA) leads to a predominant oxidation of FA for energy production, while glucose oxidation is markedly suppressed. The db/db mouse is a well accepted model of type 2 diabetes, showing hyperglycemia, hyperlipidemia, and hyperinsulinemia. Hearts from ...